Beta blocker (propranolol) and rational drug design
Betabloqueante (propranolol) y diseño racional de fármacos
- Date
- 1962-1964 · confidence high
- Place
- ICI Pharmaceuticals, Alderley Park, Cheshire, United Kingdom
- Credited to
- James Black (ICI; Nobel 1988); later cimetidine (1976) using the same method
- People
- 👤 James Whyte Black1924–2010
- Field
- Life & health
What it is
First drug designed from receptor theory to block adrenaline in the heart, against angina and hypertension. It inaugurated rational drug design.
What it led to
- Receptor-based pharmacology and the modern pharmaceutical industry
- The treatment of hypertension and the fall in cardiovascular mortality
- Anti-H2 drugs, statins and ACE inhibitors
Built on
- Total synthesis of cholesterol and cortisone1951
- receptor theory (Ahlquist)
- medicinal chemistry
Made possible
- Cimetidine1972
- Statins1976-1987
- ACE inhibitors