Chlorpromazine, first antipsychotic
Clorpromazina, primer antipsicótico
- Date
- 1952 · confidence high
- Place
- Rhône-Poulenc and Sainte-Anne Hospital, Paris, France
- Credited to
- Paul Charpentier (synthesis), Henri Laborit, Jean Delay and Pierre Deniker
- People
- 👤 Henri Laborit1914–1995👤 Jean Delay1907–1987👤 Paul Charpentier1881–1973👤 Pierre Deniker1917–1998
- Field
- Life & health
What it is
The first effective drug against psychosis, which calmed patients who had until then been confined for life. It founded psychopharmacology and emptied the asylums.
What it led to
- Psychiatric deinstitutionalisation and community psychiatry
- Antidepressants, anxiolytics and modern psychopharmacology
- The debate over the medicalisation of mental health
Built on
- Chemical neurotransmission (acetylcholine)1921-1936
- antihistamines
- phenothiazine chemistry
Made possible
- antidepressants
- benzodiazepines
- atypical antipsychotics