Cholera vaccine
Vacuna del cólera
- Date
- 1885 · confidence medium
- Place
- Valencia, Spain
- Credited to
- Jaume Ferran i Clua; later effective vaccine by Waldemar Haffkine
- Field
- Life & health
⚠️ Disputed: the sources disagree.
What was discovered
Ferran prepared a live vaccine from Vibrio cholerae strains and administered it to more than 30,000 people during the 1885 Valencia epidemic, the first mass cholera vaccination, though its efficacy was heavily disputed. Haffkine developed a version with fewer side effects in 1892 that is considered the first truly effective one.
Ferran's vaccine was the first used in humans, but its real efficacy was heavily questioned by contemporaries; Haffkine's (1892) is usually credited as the first effective human cholera vaccine.
What it led to
- Haffkine's vaccine (1892), the first recognised as effective
- Kolle's heat-killed vaccine (1896)
Built on
- Pasteur's earlier attempts at a chicken cholera vaccine