Citric acid cycle (Krebs cycle)
Ciclo del ácido cítrico (ciclo de Krebs)
- Date
- 1937 · confidence high
- Place
- University of Sheffield, England
- Credited to
- Hans Krebs and William Johnson; Albert Szent-Györgyi (precursors)
- People
- 👤 Albert Szent-Györgyi1893–1986👤 Hans Adolf Krebs1900–1981👤 William Johnson1901–1970
- Field
- Life & health
What was discovered
A central cyclic pathway in which nutrients are oxidised to CO2, releasing reducing equivalents for cellular respiration. A metabolic hub common to almost all organisms.
Nature rejected the original paper. Nobel Prize 1953.
What it led to
- metabolic biochemistry
- understanding of cellular respiration and oxidative phosphorylation
- inborn errors of metabolism
- cancer metabolism
Built on
- Cell-free alcoholic fermentation (Buchner's zymase)1897
- urea cycle (Krebs, 1932)
- Warburg's cellular respiration