Conformational analysis (Barton)
Análisis conformacional
- Date
- 1950 · confidence high
- Place
- Imperial College and Birkbeck College, London
- Credited to
- Derek Barton (building on Odd Hassel)
- People
- 👤 Derek Harold Richard Barton1918–1998
- Field
- Matter & energy
What was discovered
The reactivity of steroids and cyclohexanes is explained by the chair conformation and the axial or equatorial orientation of substituents. It adds the dynamic dimension to static stereochemistry.
Nobel Prize in Chemistry 1969 (Barton and Hassel).
What it led to
- Steroid chemistry
- Drug design
- Computational chemistry of flexible molecules
Built on
- electron diffraction of cyclohexane (Hassel, 1943)
- Van't Hoff's stereochemistry
Made possible
- Total synthesis of cholesterol and cortisone1951
- stereoselective synthesis