Cyclol
Hipótesis del ciclol
- Date
- 1936 · confidence medium
- Place
- Oxford, England, United Kingdom
- Credited to
- Dorothy Maud Wrinch
- Field
- Life & health
⚠️ Disputed: the sources disagree.
What was discovered
The first structural model of folded globular proteins, now discredited, based on cyclic (cyclol) crosslinks between peptide groups, proposed by mathematician Dorothy Wrinch in a series of papers.
A hypothesis discarded in light of later experimental evidence; catalogued for its historical relevance to the debate over protein structure.
What it led to
- intense scientific debate with Linus Pauling over protein structure
- spur to experimental X-ray research on globular proteins
- historical example of a discarded hypothesis that spurred the field forward