Diels-Alder reaction
Reacción de Diels-Alder (cicloadición)
- Date
- 1928 · confidence high
- Place
- University of Kiel, Germany
- Credited to
- Otto Diels and Kurt Alder
- People
- 👤 Kurt Alder1902–1958👤 Otto Paul Hermann Diels1876–1954
- Field
- Matter & energy
What was discovered
A diene and a dienophile form a six-membered ring in a single step with stereochemical control. A central tool in the synthesis of natural products and the textbook example of a pericyclic reaction.
Nobel Prize in Chemistry 1950.
What it led to
- Total synthesis of steroids and alkaloids
- Woodward-Hoffmann rules
- Materials chemistry (self-healing polymers)
Built on
- diene chemistry
- structural theory
Made possible
- Total synthesis of cholesterol and cortisone1951
- synthesis of cortisone and reserpine