DNA gyrase
ADN girasa
- Date
- 1976 · confidence high
- Place
- Bethesda, Maryland, United States
- Credited to
- Martin Gellert
- Field
- Life & health
What was discovered
A bacterial enzyme discovered by Martin Gellert that introduces negative supercoiling into circular DNA using ATP, and which is the target of antibiotics such as quinolones.
What it led to
- Development of quinolone and fluoroquinolone antibiotics
- Understanding of DNA supercoiling during replication
- Identification of related gyrases in apicoplasts and chloroplasts
- A drug target in antimalarial research