Doebner reaction
Síntesis de quinolinas de Doebner
- Date
- 1887 · confidence medium
- Place
- Halle, Saxony-Anhalt, Germany
- Credited to
- Oskar Doebner
- Field
- Matter & energy
What was discovered
Chemical reaction in which an aniline reacts with an aldehyde and pyruvic acid to form quinoline-4-carboxylic acids; serves as an alternative synthetic route to the Pfitzinger reaction.
What it led to
- Synthesis of quinoline derivatives in pharmaceutical chemistry
- Expansion of methods for building nitrogen heterocycles
- Use in preparing precursors for antimalarial and antibacterial drugs