(+)-epibatidine
Epibatidina
- Date
- 1974 · confidence medium
- Place
- Bethesda, Maryland, United States
- Credited to
- John W. Daly
- Field
- Matter & energy
What was discovered
John Daly isolated epibatidine from the skin of an Ecuadorian frog, a potent natural painkiller chemically unrelated to opioids; its full structure was not confirmed until 1992.
What it led to
- Research into non-opioid painkillers
- Study of nicotinic acetylcholine receptors
- Chemistry of poison-frog alkaloids
- Total laboratory synthesis of epibatidine