Hepatitis C cure with direct-acting antivirals (sofosbuvir)
Cura de la hepatitis C con antivirales de acción directa (sofosbuvir)
- Date
- 2013 · confidence high
- Place
- Pharmasset, Princeton, and Gilead Sciences, Foster City, California, United States
- Credited to
- Michael Sofia (Pharmasset); Gilead (Sovaldi, 2013; Harvoni, 2014)
- People
- 👤 Michael J. Sofia1958–
- Field
- Life & health
What it is
First oral treatment that cures a chronic viral infection in more than 95 per cent of cases within twelve weeks. It made the elimination of hepatitis C possible.
What it led to
- The elimination of hepatitis C as a public health goal (Egypt)
- The debate over an 84,000-dollar price per treatment and access
- The design of antivirals against SARS-CoV-2 (remdesivir, Paxlovid)
Built on
- HIV antiretrovirals (AZT and combination therapy)1987-1996
- HIV antiretrovirals
- hepatitis C replicon
- nucleotide chemistry
Made possible
- Paxlovid
- elimination of hepatitis C