Human microbiome
Microbioma humano como órgano funcional
- Date
- 2007-2012 · confidence high
- Place
- NIH, Bethesda (Human Microbiome Project) / Washington University, St. Louis
- Credited to
- Human Microbiome Project; Jeffrey Gordon, Rob Knight; precursors: Metchnikoff, Carl Woese (16S)
- People
- 👤 Carl Woese1928–2012👤 Rob Knight1976–
- Field
- Life & health
What was discovered
Massive 16S RNA sequencing and metagenomics revealed trillions of microbes in the body that influence digestion, immunity, metabolism and the brain, with profiles linked to obesity and disease.
What it led to
- faecal microbiota transplantation
- probiotics and personalised nutrition
- the gut-brain axis
- precision medicine based on the microbiota
Built on
- Probiotic Lactobacillus casei Shirota (Yakult)1930-1935
- Next-generation sequencing (454, Solexa/Illumina)2005-2006
- Woese's phylogeny
- gnotobiology
Made possible
- metagenomics
- standardised faecal transplant