🛠️ Invention or technique

Java cinchona plantations and the ledgeriana variety

Plantaciones de cinchona en Java y la variedad ledgeriana

Date
1854-1880 · confidence high
Place
Lembang, West Java, Indonesia
Credited to
Franz Wilhelm Junghuhn, Justus Karl Hasskarl and Charles Ledger (seeds), Dutch colonial administration
Field
Life & health

⚠️ Disputed: the sources disagree.

What it is

The Dutch brought cinchona to Java from 1854 and, from 1865, cultivated the ledgeriana variety (up to 13% quinine) from Bolivian seeds. In the 20th century Java came to produce over 90% of the world's quinine.

Credit for the ledgeriana seeds is disputed: Ledger and his Bolivian servant Manuel Incra Mamani obtained them in 1865; the Dutch government bought them from Ledger and the British declined the offer. Mamani died tortured in Bolivia.

What it led to

  • abundant, cheap quinine to treat and prevent malaria in the colonies
  • the Dutch quinine cartel (Kina Bureau)
  • a shift of research towards synthetic drugs (chloroquine) after the 1942 war
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Sources✓ verified 2026-11-04