🔬 Discovery

LSD and the discovery of its psychoactive effects

LSD y el descubrimiento de sus efectos psicoactivos

Date
1938 (síntesis) / 1943 (efectos psicoactivos) · confidence high
Place
Sandoz Laboratories, Basel, Switzerland
Credited to
Albert Hofmann
Field
Life & health

What was discovered

Hofmann synthesised lysergic acid diethylamide in 1938 while searching for a circulatory stimulant; five years later, after accidental re-exposure, he deliberately dosed himself on 19 April 1943 and discovered its intense psychoactive effects while cycling home.

'Bicycle Day' (19 April 1943) is commemorated annually as the birth of modern psychedelia.

What it led to

  • Psychopharmacology and the scientific study of altered states of consciousness
  • Experimental use in psychiatry during the 1950s-60s
  • Legal prohibition of LSD (1966-1971) and the end of open clinical research

Built on

  • Ergot alkaloids

Made possible

  • Psychedelic drugs for therapeutic use

Links

Sources✓ verified 2026-09-25