🔬 Discovery

Mallory–Weiss syndrome

Desgarro de Mallory-Weiss

Date
1929 · confidence medium
Place
Boston, Massachusetts, United States
Credited to
George Kenneth Mallory and Soma Weiss
Field
Life & health

What was discovered

A syndrome marked by mucosal tears at the gastroesophageal junction, caused by intense vomiting or retching, leading to upper gastrointestinal bleeding; described by Mallory and Weiss in 1929.

What it led to

  • recognition of a common cause of acute upper GI bleeding
  • a diagnostic link to alcoholism and bulimia
  • routine diagnosis by upper gastrointestinal endoscopy
  • differentiation from other causes of hematemesis, such as esophageal varices

Links

Sources✓ verified 2026-09-28