Mwanza trial: treating sexually transmitted infections reduces HIV
Ensayo de Mwanza: tratar las infecciones de transmisión sexual reduce el VIH
- Date
- 1991-1995 · confidence high
- Place
- Mwanza, Tanzania
- Credited to
- Heiner Grosskurth, Gina Mosha, Richard Hayes and the Mwanza Intervention Trial
- Field
- Life & health
What was discovered
A community trial in eight communities that showed syndromic management of sexually transmitted infections cut HIV incidence by about 40%. It was the first prevention intervention with proven efficacy against HIV.
Published in The Lancet (1995, 42% reduction). Later trials in Rakai and Masaka (Uganda) did not confirm the effect, qualifying its generalisation to more advanced epidemics.
What it led to
- STI care programmes for HIV prevention in Africa
- later re-evaluation with negative trials in Rakai and Masaka
- evidence for the design of randomised community interventions