Randomized controlled trial
Ensayo clínico aleatorizado controlado
- Date
- 1948 · confidence high
- Place
- Medical Research Council, London, England
- Credited to
- Austin Bradford Hill (streptomycin trial in tuberculosis)
- People
- 👤 Austin Bradford Hill1897–1991
- Field
- Life & health
What was discovered
Random allocation of patients to treatment or control to eliminate bias. It became the gold standard for proving that a treatment works.
What it led to
- evidence-based medicine
- drug regulation (FDA, EMA) based on trials
- Bradford Hill's criteria for causation and the epidemiology of tobacco
- meta-analysis and Cochrane
Built on
- Streptomycin1943
- Lind's trial (1747)
- Fisher's statistics
Made possible
- Smoking causes lung cancer1950-1954
- pharmacovigilance
- phase I-III drug development