Rauwolfia serpentina as antihypertensive
Rauwolfia serpentina como antihipertensivo
- Date
- 1931 · confidence high
- Place
- Calcutta (Kolkata), West Bengal, India
- Credited to
- Ganapati Sen and Kartick Chandra Bose; Salimuzzaman Siddiqui
- People
- 👤 Salimuzzaman Siddiqui1897–1994
- Field
- Life & health
⚠️ Disputed: the sources disagree.
What was discovered
Sen and Bose published the hypotensive and sedative effect of the root of Indian snakeroot, used in traditional medicine, and Siddiqui isolated its alkaloids in Delhi that same year. Reserpine, purified in 1952, was one of the first effective drugs against hypertension.
The isolation of reserpine was done by Müller, Schlittler and Bein at CIBA (Basel, 1952); Indian priority lies in the clinical use and early pharmacology.
What it led to
- reserpine as an antihypertensive and antipsychotic
- monoamine hypothesis of depression