Retrosynthetic analysis (Corey)
Análisis retrosintético
- Date
- 1967 · confidence high
- Place
- Harvard University, Cambridge, Massachusetts, United States
- Credited to
- Elias James Corey
- People
- 👤 Elias James Corey1928–
- Field
- Matter & energy
What was discovered
A logical method for planning syntheses by disconnecting the target molecule into simpler precursors, synthons and synthetic equivalents. It turns synthesis into a teachable, programmable discipline (LHASA, 1969).
Nobel Prize in Chemistry 1990.
What it led to
- Computer-assisted synthesis
- Industrial medicinal chemistry
- Synthesis of prostaglandins and ginkgolides
Built on
- Organic reaction mechanisms (Ingold, Hughes)1930-1935
- Woodward's total syntheses
- Ingold's mechanisms
Made possible
- Total synthesis of Taxol1994
- synthesis planning programs
- Corey's reagents (PCC, TBS)