Single-dose nevirapine to prevent mother-to-child HIV transmission (HIVNET 012)
Prevención de la transmisión maternoinfantil del VIH con nevirapina
- Date
- 1999 · confidence high
- Place
- Mulago Hospital, Kampala, Uganda
- Credited to
- Laura Guay, Philippa Musoke, Brooks Jackson and colleagues (Makerere University-Johns Hopkins)
- People
- 👤 Brooks Jackson1953–👤 Laura A Guay👤 Philippa Musoke
- Field
- Life & health
What it is
A trial showing that one dose of nevirapine to the mother during labour and another to the newborn reduced HIV transmission by almost half. It was a cheap regimen applicable in poor countries.
Published in The Lancet (1999). The emergence of resistance later led to combined regimens.
What it led to
- PMTCT programmes worldwide
- millions of childhood infections prevented
- the later shift to lifelong antiretroviral treatment for pregnant women