🛠️ Invention or technique

Smallpox inoculation in Bengal (tika)

Inoculación de la viruela en Bengala (tika)

Date
before 1767 · confidence low
Place
Calcutta (Kolkata), West Bengal, India
Credited to
Itinerant Brahmin inoculators
Field
Life & health

⚠️ Disputed: the sources disagree.

What it is

Inoculators made a small incision and inserted matter from smallpox pustules from the previous year, followed by a regimen of cold water and diet, to induce a mild form that granted immunity. The physician J. Z. Holwell described it to the Royal College of Physicians in London in 1767.

The antiquity of the practice is disputed: some authors consider it very old and others believe it was introduced in the 18th century. It reached England via Constantinople (1721), not from India.

What it led to

  • popular immunisation in eastern India
  • European debate on variolation

Links

Sources✓ verified 2026-09-23