Thrombotic thrombocytopenic purpura
Púrpura trombocitopénica trombótica
- Date
- 1924 · confidence high
- Place
- New York, United States
- Credited to
- Eli Moschcowitz
- Field
- Life & health
What was discovered
A blood disorder causing clots in small vessels, first described by Eli Moschcowitz; it is now known to typically result from inhibition of the enzyme ADAMTS13.
Plasma exchange reduced mortality from more than 90% to less than 20%.
What it led to
- Plasma exchange treatment
- Discovery of the role of ADAMTS13 and von Willebrand factor