Angiotensin (hypertensin)
Angiotensina (hipertensina)
- Date
- 1939-1940 · confidence high
- Place
- Institute of Physiology, Buenos Aires, Argentina
- Credited to
- Eduardo Braun-Menéndez, Juan Carlos Fasciolo, Luis F. Leloir, Juan M. Muñoz
- People
- 👤 Eduardo Braun Menéndez1903–1959👤 Juan Carlos Fasciolo1911–1993👤 Luis Federico Leloir1906–1987
- Field
- Life & health
⚠️ Disputed: the sources disagree.
What was discovered
The Argentine group identified the vasoconstrictor substance formed by renin in the blood, which they called hypertensin. It is the basis of the renin-angiotensin system and of ACE-inhibitor antihypertensive drugs.
Page and Helmer (Indianapolis) discovered it simultaneously as 'angiotonin'; in 1958 both groups agreed on the name angiotensin.
What it led to
- the renin-angiotensin system
- ACE inhibitors (captopril, 1975)
- modern treatment of hypertension