Artemisinin resistance in malaria (Pailin)
Resistencia del paludismo a la artemisinina (Pailin)
- Date
- 2008-2014 · confidence high
- Place
- Pailin, Cambodia
- Credited to
- Harald Noedl, Arjen Dondorp and Mahidol-Oxford teams (Thailand); kelch13 gene: Frédéric Ariey
- Field
- Life & health
What was discovered
In 2008-2009 clinical studies in Pailin showed that Plasmodium falciparum parasites were slower to clear with artemisinin. In 2014 the resistance was linked to mutations in the kelch13 gene.
The earliest signs on the Thai-Cambodian border date from the 1950s with chloroquine and with sulfadoxine-pyrimethamine; artemisinin resistance was clinically documented in 2008-2009.
What it led to
- artemisinin combination therapies and surveillance in the Greater Mekong Subregion
- kelch13 molecular marker for global monitoring
- resistance also detected in Rwanda and Uganda (2020-2024)