Artesunate-mefloquine combination therapy on the Thai border
Terapia combinada con artesunato y mefloquina en la frontera tailandesa
- Date
- c. 1991-1996 · confidence medium
- Place
- Mae Sot, Tak, Thailand
- Credited to
- Shoklo Malaria Research Unit (Nosten, White and colleagues)
- Field
- Life & health
⚠️ Disputed: the sources disagree.
What it is
A combination of artesunate (an artemisinin derivative) with mefloquine for falciparum malaria, trialled on the Thai-Burmese border and adopted in Thailand from the mid-1990s. It reduced malaria and slowed mefloquine resistance.
Priority for the artemisinin combination concept is disputed: Chinese and Vietnamese researchers tested combinations in the 1980s and 1990s, and Nosten and White's work (with trials of 1991-1994 published in 2000) set the standard of fixed combination.
What it led to
- artemisinin combination therapies (ACT) as the world standard
- WHO recommendations (2001-2006) on ACT
- monitoring of artemisinin resistance in the Mekong