Bradykinin-potentiating factor and captopril
Factor potenciador de bradicinina y captopril
- Date
- 1965-1981 · confidence medium
- Place
- Faculty of Medicine, Ribeirão Preto, São Paulo, Brazil
- Credited to
- Sérgio Ferreira, John Vane, Miguel Ondetti and David Cushman
- Field
- Life & health
What was discovered
Ferreira found in jararaca venom a peptide that potentiates bradykinin and inhibits angiotensin-converting enzyme. It served to design captopril, the first ACE inhibitor for hypertension.
The factor was discovered in 1965 in Brazil and developed in London and at Squibb (USA); captopril reached the market in 1981. Ferreira is recognised as discoverer, but did not share Vane's 1982 Nobel.
What it led to
- ACE inhibitors for hypertension and heart failure
- Rational drug design from toxins
- Enalapril and lisinopril