Enzymes are proteins (urease crystallized)
Las enzimas son proteínas (cristalización de la ureasa)
- Date
- 1926 · confidence high
- Place
- Cornell University, Ithaca, United States
- Credited to
- James B. Sumner; John Northrop (pepsin, 1930)
- People
- 👤 James Batcheller Sumner1887–1955👤 John Howart Northrop1891–1987
- Field
- Life & health
What was discovered
He crystallised urease and demonstrated that it was a protein, against Willstätter's view. Biological catalysts became defined, studiable molecules.
Nobel Prize 1946.
What it led to
- enzymology and enzyme kinetics
- structural biochemistry
- the enzyme industry
- one gene-one enzyme (Beadle and Tatum, 1941)
Built on
- Buchner's ferments (1897)
- Michaelis-Menten kinetics (1913)
Made possible
- Ubiquitin-mediated protein degradation1978-1980
- industrial enzymes