Imatinib (Gleevec), first targeted cancer therapy
Imatinib (Gleevec), primera terapia dirigida contra el cáncer
- Date
- 2001 · confidence high
- Place
- Novartis, Basel, Switzerland; Oregon Health & Science University, Portland
- Credited to
- Brian Druker (OHSU), Nicholas Lydon and Jürg Zimmermann (Novartis)
- People
- 👤 Brian Druker1955–👤 Jürg Zimmermann1943–👤 Nicholas Lydon1957–
- Field
- Life & health
What it is
Drug designed to block the mutant protein that causes chronic myeloid leukaemia, turning it into a chronic disease. It inaugurated precision oncology.
What it led to
- Molecular oncology based on mutations and the hundreds of kinase inhibitors
- Tumour sequencing as clinical practice
- The price of cancer drugs
Built on
- Human Genome Project1990-2003
- Human Genome Project
- Philadelphia chromosome
- medicinal chemistry
Made possible
- kinase inhibitors
- precision oncology
- liquid biopsy