Insulin amino acid sequence (Sanger)
Secuencia de aminoácidos de la insulina: las proteínas tienen secuencia definida
- Date
- 1951-1955 · confidence high
- Place
- University of Cambridge, United Kingdom
- Credited to
- Frederick Sanger
- People
- 👤 Frederick Sanger1918–2013
- Field
- Life & health
What was discovered
He determined the complete amino acid sequence of insulin, proving that every protein has a unique, genetically defined sequence. Sanger's first Nobel Prize (1958).
What it led to
- the concept that genes encode sequences
- Crick's sequence hypothesis
- proteomics
- synthetic insulin
Built on
- Chromatography1903-1906
- Total synthesis of crystalline bovine insulin1965
- paper chromatography
Made possible
- Central dogma of molecular biology1957-1958
- Molecular clock and neutral theory1962-1968
- Total synthesis of crystalline bovine insulin1965
- automated protein sequencing (Edman)