Messenger RNA
ARN mensajero
- Date
- 1961 · confidence high
- Place
- Pasteur Institute, Paris / Caltech / Cambridge
- Credited to
- Sydney Brenner, François Jacob, Matthew Meselson; Jacob and Monod (concept)
- People
- 👤 François Jacob1920–2013👤 Matthew Meselson1930–👤 Sydney Brenner1927–2019👤 Théodore Monod1902–2000
- Field
- Life & health
What was discovered
They demonstrated that an unstable RNA copied from DNA carries information to pre-existing ribosomes, solving how information is transmitted from gene to protein.
What it led to
- cracking the genetic code
- gene regulation
- mRNA vaccines (2020)
- transcriptomics
Built on
- Central dogma of molecular biology1957-1958
- PaJaMo experiment
Made possible
- Discovery of introns1977
- Nucleoside modification of mRNA (pseudouridine) to avoid immune response2005
- mRNA vaccines
- RNA therapies