Oncogenes (cellular origin)
Oncogenes: origen celular de los genes del cáncer
- Date
- 1970-1976 · confidence high
- Place
- UCSF, San Francisco, United States
- Credited to
- J. Michael Bishop and Harold Varmus; Peyton Rous (sarcoma virus, 1911), Robert Weinberg (human RAS, 1982)
- People
- 👤 Harold E. Varmus1939–👤 John Michael Bishop1936–2026👤 Peyton Rous1879–1970👤 Robert Weinberg1942–
- Field
- Life & health
What was discovered
The src gene of Rous sarcoma virus is an altered version of a normal cellular gene: cancer arises from mutation of the body's own genes that control growth.
Nobel Prize 1989.
What it led to
- molecular oncology
- targeted therapies (imatinib, 2001)
- tumour genetic panels
- the multistage model of cancer
Built on
- Rous sarcoma virus
- somatic mutation theory (Boveri)