p53 tumor suppressor
p53, guardián del genoma
- Date
- 1979-1989 · confidence high
- Place
- Imperial Cancer Research Fund, London / Princeton / Johns Hopkins
- Credited to
- David Lane, Lionel Crawford, Arnold Levine (1979); Bert Vogelstein (tumour suppressor, 1989)
- People
- 👤 Arnold J. Levine1939–👤 Bert Vogelstein1949–👤 David Lane1938–2007👤 Lionel Crawford1932–2024
- Field
- Life & health
What was discovered
A protein that halts the cell cycle or induces apoptosis in response to DNA damage; its gene is mutated in more than half of human tumours. It consolidated the concept of the tumour suppressor gene (alongside Knudson's RB).
For a decade it was mistakenly believed to be an oncogene.
What it led to
- biology of apoptosis and the cell cycle
- Li-Fraumeni syndrome and hereditary cancer
- Vogelstein's model of tumour progression
- drugs that reactivate p53
Built on
- Oncogenes (cellular origin)1970-1976
- Knudson's two-hit hypothesis (1971)