Serotonin isolated and identified
Serotonina aislada e identificada
- Date
- 1948 · confidence high
- Place
- Cleveland Clinic, Cleveland, Ohio, United States
- Credited to
- Maurice M. Rapport, Arda Green and Irvine Page
- Field
- Life & health
What was discovered
Irvine Page's team at the Cleveland Clinic isolated and chemically characterized the vasoconstrictor agent in blood serum, which Rapport, Green and Page named serotonin; it was soon after identified as a brain neurotransmitter.
What it led to
- The birth of monoamine neurotransmitter neurochemistry
- Development of drugs acting on the serotonergic system (antidepressants, anti-migraine drugs)
- The serotonin hypothesis of depression and other mood disorders