Thyroxine
Tiroxina, hormona tiroidea
- Date
- 1914 · confidence high
- Place
- Mayo Clinic, Rochester, Minnesota, United States
- Credited to
- Edward Calvin Kendall; synthesis by Charles Harington (1926)
- People
- 👤 Edward Calvin Kendall1886–1972
- Field
- Life & health
What was discovered
Crystalline isolation of the thyroid hormone from tonnes of pig thyroid, explaining goitre, cretinism and myxoedema as a treatable hormone deficiency.
Kendall received the Nobel Prize in 1950 for cortisone.
What it led to
- treatment of hypothyroidism
- iodisation of salt and prevention of endemic goitre
- clinical endocrinology
Built on
- Hormones and internal secretion (secretin)1902-1905
- Murray's thyroid extracts (1891)
- concept of the hormone
Made possible
- Iodised salt1922
- Testosterone, first male sex hormone isolated1935
- synthetic levothyroxine