Base editing and prime editing
Edición de bases y edición prime
- Date
- 2016-2019 · confidence high
- Place
- Broad Institute and Harvard University, Cambridge, Massachusetts, United States
- Credited to
- David Liu, Alexis Komor and Nicole Gaudelli (base editing, 2016); Andrew Anzalone and David Liu (prime editing, 2019)
- People
- 👤 Alexis Komor👤 Andrew V Anzalone👤 David Liu1967–👤 Nicole M Gaudelli
- Field
- Life & health
What it is
Variants of CRISPR that change a single letter of DNA without cutting the double strand, with greater precision and safety. In 2025 they were used for the first custom-made personalised treatment for a baby.
What it led to
- Personalised therapies for rare diseases (the KJ case, 2025)
- The correction of point mutations in heart and liver diseases
- The reduction of off-target effects
Built on
- CRISPR-Cas9 genome editing2012
- deaminases
- reverse transcriptase
Made possible
- personalised in vivo editing therapy (2025)
- correction of point mutations