Dolly the sheep (somatic cell nuclear transfer)
Clonación de la oveja Dolly por transferencia nuclear
- Date
- 1996 · confidence high
- Place
- Roslin Institute, Edinburgh, Scotland
- Credited to
- Ian Wilmut and Keith Campbell
- People
- 👤 Ian Wilmut1944–2023👤 Keith Campbell1954–2012
- Field
- Life & health
What was discovered
The first mammal cloned from an adult cell, demonstrating that a differentiated nucleus can be fully reprogrammed. Announced in February 1997.
Gurdon shared the 2012 Nobel Prize with Yamanaka.
What it led to
- cell reprogramming and iPS cells
- cloning of farm animals and pets
- bans on human reproductive cloning
- the debate over therapeutic cloning
Built on
- Frog cloning by nuclear transfer (Gurdon)1962
- nuclear transfer in frogs (Briggs and King, Gurdon 1962)
- cell culture
Made possible
- Human embryonic stem cells and iPS cells1998-2006
- Snuppy, the first cloned dog2005
- Primate cloning by somatic cell nuclear transfer2018
- Gene-edited pig organ xenotransplantation2021-2024
- mammalian cloning
- pharmaceutical transgenic animals