Gene-edited pig organ xenotransplantation
Xenotrasplante de riñón y corazón de cerdo editado
- Date
- 2021-2024 · confidence medium
- Place
- NYU Langone, New York (kidney, 2021); University of Maryland, Baltimore (heart, 2022); Massachusetts General Hospital, Boston (kidney in a living patient, 2024)
- Credited to
- Robert Montgomery (NYU); Bartley Griffith and Muhammad Mohiuddin (Maryland); Tatsuo Kawai (MGH); pigs from eGenesis and Revivicor with dozens of CRISPR edits
- People
- 👤 Muhammad Mohiuddin👤 Tatsuo Kawai1973–
- Field
- Life & health
What it is
Transplantation into humans of organs from pigs with multiple gene edits to avoid rejection. The first living recipients survived for months, with longer survival in 2025.
What it led to
- A possible solution to the organ shortage
- Pharmaceutical farming of gene-edited animals
- Ethical debates over animals and the risk of porcine viruses
Built on
Made possible
- on-demand pig organs
- formal xenotransplantation clinical trials (2025)